Chinese Journal of Tissue Engineering Research ›› 2014, Vol. 18 ›› Issue (31): 5036-5043.doi: 10.3969/j.issn.2095-4344.2014.31.020
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Liu Meng-jun1, Du Bin1, Wei Xin-wei1, Wang Shi-hai1, Lin Qing1, Wang Song1, Chen Zhi-xin2
Received:
2014-06-29
Online:
2014-07-23
Published:
2014-07-23
Contact:
Chen Zhi-xin, M.D., Chief physician, First Department of Orthopedics, Gansu Provincial People’s Hospital, Lanzhou 730000, Gansu Province, China
About author:
Liu Meng-jun, Studying for master’s degree, First Clinical Medical College of Lanzhou University, Lanzhou 730000, Gansu Province, China
CLC Number:
Liu Meng-jun, Du Bin, Wei Xin-wei, Wang Shi-hai, Lin Qing, Wang Song, Chen Zhi-xin. Microsurgical discectomy versus microendoscopic discectomy for treatment of lumbar disc herniations: a meta-analysis[J]. Chinese Journal of Tissue Engineering Research, 2014, 18(31): 5036-5043.
2.1 文献描述 文献管理软件去重后获得145篇相关对照研究,其中中文56篇,英文89篇,阅读题名、摘要后排除综述、动物实验、研究方法不符合要求、重复发表、结局指标不符合要求的文献135篇。对剩余10篇文献通过查看全文,排除了未达到纳入标准的5篇文献,最终纳入的5篇随机对照试验文献[29-33],共包括1 430例椎间盘突出患者(见图1),所有文献均对其基本情况进行比较,各组基线有一致性。纳入文献特征见表1。2.2 方法学质量评价 对所纳入文献按RevMan 5.2软件提供的质量评价标准进行偏倚风险评价:①随机方法是否正确。②是否采用分配隐藏。③是否采用盲法。④结果数据的完整性。⑤是否有选择性报告结果。⑥其他偏倚。结果见表2。"
2.3 Meta分析结果 2.3.1 手术时间 4个研究比较了手术时间[30-33],各研究间存在统计学异质性(P=0.000 7,I2=82%),采用随机效应模型合并后进行Meta分析?结果显示两组差异有显著性意义[MD= -10.13(-14.06,-6.21),P < 0.000 01],说明显微椎间盘切除比显微内窥镜下椎间盘切除手术用时短(图2)? 2.3.2 住院时间 4个研究比较了住院时间[30-33],各研究间无统计学异质性(P=0.56,I2=0%),采用固定效应模型合并后进行Meta分析?结果显示两组差异无显著性意义[MD= -0.19(-0.43,0.05),P=0.13],说明显微椎间盘切除与显微内窥镜下椎间盘切除住院时间相当(图3)? 2.3.3 术中出血量 4个研究比较了术中出血量[30-33],各研究间存在统计学异质性(P < 0.000 01,I2=98%),采用随机效应模型合并后进行Meta分析?结果显示两组差异有显著性意义[MD=-24.27(-39.45,-9.08),P=0.002],说明显微椎间盘切除比显微内窥镜下椎间盘切除术中出血量少(图4)? 2.3.4 ODI改善率 2个研究比较了两组ODI改善率[30-31],各研究间存在统计学异质性(P < 0.000 1,I2=94%),采用随机效应模型合并后进行Meta分析?结果显示两组差异无显著性意义[MD=2.78 (-0.15,5.72),P=0.06],说明显微椎间盘切除与显微内窥镜下椎间盘切除在ODI改善率方面相当(图5)?"
2.3.5 目测类比评分改善率 2个研究比较了目测类比评分改善率[30-31],各研究间存在统计学异质性(P < 0.000 01, I,采用随机效应模型合并后进行Meta分析?结果显示两组差异无显著性意义[MD=1.96(-0.29,4.21), P,说明显微椎间盘切除与显微内窥镜下椎间盘切除在目测类比评分改善率方面相当(图6)?=0.09]2=99%) 2.3.6 硬脊膜撕裂 4研究比较了硬脊膜撕裂[29-32],各研究间无统计学异质性(P=0.94,I2=0%),采用固定效应模型合并后进行Meta分析?结果显示两组差异有显著性意义[RR=0.28(0.11,0.68),P=0.005],说明显微椎间盘切除比显微内窥镜下椎间盘切除硬脊膜撕裂发生率低(表3)? 2.3.7 复发 3个研究比较了复发[29, 31-32],各研究结果间无统计学异质性(P=0.81,I2=0%),采用固定效应模型合并后进行Meta分析?结果显示两组差异无显著性意义[RR= 0.34(0.14,0.83),P=0.02],说明显微椎间盘切除比显微内窥镜下椎间盘切除复发率低(表3)? 2.3.8 神经根损伤 2个研究比较了神经根损伤[29, 31],各研究结果间无统计学异质性(P=1.00,I2=0%),采用固定效应模型合并后进行Meta分析?结果显示两组差异无显著性意义[RR=0.20(0.03,1.12),P=0.07],说明两种微创方式在神经根损伤方面相当(表3)。"
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